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Statins have no desired effect for half of patients, study findings Society



Nearly half of patients prescribed statins do not see their cholesterol drop to desired levels for two years, new research suggests.

Guidelines from the National Institute for Health and Care Excellence (Nice) reduce the low density lipoprotein cholesterol from treatment.

However, a new study, published in the journal Heart, found half of people (51%) had a "sub-optimal" response after 24 months of the drugs. Researchers, from the University of Nottingham, studied data from 1

65,411 patients prescribed statins for primary care between 1990 and 2016.

They were at average 62 years old when they started treatment .

A total of 84,609 patients had a "sub-optimal" response after two years and did not record cholesterol reduction by 40% or more.

Researchers found that a higher proportion of patients with "sub-optimal" response was prescribed by a lower dose of potency, co

Patients who did not reach target levels is 22% more likely to develop cardiovascular disease than those who respond well, study finds.

Researchers say that the study provides "The real world evidence" about statins.

"The findings contribute to the debate on the effectiveness of statin therapy and highlight the need for personalized lipid-management drugs for patients," they wrote.

Professor Metin Avkiran, director of the British Heart Foundation, states: "Statins are an important and proven treatment for lowering cholesterol and reducing the risk of a potentially deadly heart attack or stroke.

" Although this study indicates that not all prescribed statins manage to reduce their cholesterol adequately, it does not explain why.

"These people may be prescribed low doses or low statins potency, they ar and do not take medication as prescribed, or they do not respond well to the type of statins they prescribed.

" If you have prescribed statins you should continue to take them regularly, as prescribed.

"If you have any concerns you should discuss your medication with your GP.

Professor Helen Stokes-Lampard, chairman of the Royal College of GPs, states:" When we prescribe a drug, we must rely on to patients to make sure they take it, both in the recommended dosage and in the period of time that we think will benefit them.

"There is a large body of research that shows statins is safe and effective medicine for most people, and can reduce the risk of heart attacks and strokes, when prescribed appropriately – but controversy remains surrounding with their widespread use and their potential impact.

"There are complex reasons why patients do not choose their prescription drugs, and mix ed messaging around statins can be one of them. "


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